Toward the total synthesis of spirastrellolide A. Part 3: Intelligence gathering and preparation of a ring-expanded analogue

Literature Information

Publication Date 2007-06-26
DOI 10.1039/B707835H
Impact Factor 6.222
Authors

Alois Fürstner, Bernhard Fasching, Gregory W. O'Neil, Michaël D. B. Fenster, Cédrickx Godbout, Julien Ceccon


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Abstract

Different methods for the formation of the C.25–C.26 bond of spirastrellolide A (1) are evaluated that might qualify for the end game of the projected total synthesis, with emphasis on metathetic ways to forge the macrocyclic frame.

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