Carboranyl thymidine analogues for neutron capture therapy

Literature Information

Publication Date 2007-08-15
DOI 10.1039/B707257K
Impact Factor 6.222
Authors

Rohit Tiwari, Youngjoo Byun, Sureshbabu Narayanasamy


View Original

Abstract

Neutron capture therapy (NCT) is a binary radio-chemotherapeutic modality for the treatment of cancer. A major focus of NCT-related research is the development of novel tumor-selective agents that serve as the chemical component in NCT. Thymidine analogues substituted with a boron-containing carborane cluster at the N3 position, designated 3CTAs (3-carboranyl thymidine analogues), constitute one class of these new improved NCT agents. Their chemical, structural and biological properties are discussed in this Feature Article.

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