A Ramberg–Bäcklund route to the stilbenoid anti-cancer agents combretastatin A-4 and DMU-212
Literature Information
James E. Robinson, Richard J. K. Taylor
A concise route to combretastatin A-4, a potent inhibitor of tubulin polymerisation, using a Ramberg–Bäcklund reaction to form the key (Z)-stilbene unit has been developed; this Ramberg–Bäcklund approach has also been extended to prepare the (E)-stilbene DMU-212, which also possesses interesting growth inhibitory properties.
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