Dynamic kinetic resolution of 2-oxo-3-aryl-succinates by organocatalyzed aldolization

Literature Information

Publication Date 2007-01-12
DOI 10.1039/B616382C
Impact Factor 6.222
Authors

Yajun Wang, Zongxuan Shen, Bin Li, Yong Zhang, Yawen Zhang


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Abstract

The dynamic kinetic resolution of 2-oxo-3-arylsuccinates was achieved viaL-proline-catalyzed addition of acetone in acetonitrile at room temperature, providing the desired adduct in good yield with up to 87 : 13 dr and high ee up to 99%.

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