Dynamic kinetic resolution of 2-oxo-3-aryl-succinates by organocatalyzed aldolization
Literature Information
Yajun Wang, Zongxuan Shen, Bin Li, Yong Zhang, Yawen Zhang
The dynamic kinetic resolution of 2-oxo-3-arylsuccinates was achieved viaL-proline-catalyzed addition of acetone in acetonitrile at room temperature, providing the desired adduct in good yield with up to 87 : 13 dr and high ee up to 99%.
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![5,7-Dihydroxy-3-(4-hydroxyphenyl)-6-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]chromen-4-one structure 5,7-Dihydroxy-3-(4-hydroxyphenyl)-6-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]chromen-4-one structure](https://static.chemtradehub.com/structs/191/1914963-20-4-2b05.webp)


