New insights into the enantioselectivity in the hydrogenation of prochiral ketones
Literature Information
Samuel A. French, Devis Di Tommaso, Antonio Zanotti-Gerosa, Fred Hancock
The high enantioselectivity in the hydrogenation of acetophenone catalysed by trans-Ru(H)2(S,S-dpen)(S-xylbinap) is explained in terms of the existence of a stable intermediate formed when the reactant enters the catalyst pocket fixing the molecular orientation.
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Chemical Communications

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