New insights into the enantioselectivity in the hydrogenation of prochiral ketones

Literature Information

Publication Date 2007-03-12
DOI 10.1039/B616210J
Impact Factor 6.222
Authors

Samuel A. French, Devis Di Tommaso, Antonio Zanotti-Gerosa, Fred Hancock


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Abstract

The high enantioselectivity in the hydrogenation of acetophenone catalysed by trans-Ru(H)2(S,S-dpen)(S-xylbinap) is explained in terms of the existence of a stable intermediate formed when the reactant enters the catalyst pocket fixing the molecular orientation.

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