Development of a pharmaceutical cocrystal of a monophosphate salt with phosphoric acid
Literature Information
Alex M. Chen, Martha E. Ellison, Andrey Peresypkin, Robert M. Wenslow, Narayan Variankaval, Cecile G. Savarin, Theresa K. Natishan, David J. Mathre, Peter G. Dormer, Danielle H. Euler, Richard G. Ball, Zhixiong Ye, Yaling Wang, Ivan Santos
We report the first case of a pharmaceutical cocrystal formed between an inorganic acid and an active pharmaceutical ingredient (API), which enabled us to develop a stable crystalline and bioavailable solid dosage form for pharmaceutical development where otherwise only unstable amorphous free form or salts could have been used.
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