The direct α-zincation of amides, phosphonates and phosphine oxides by H–Zn exchange

Literature Information

Publication Date 2005-09-23
DOI 10.1039/B509190J
Impact Factor 6.222
Authors

Mark L. Hlavinka, Jeffrey F. Greco, John R. Hagadorn


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Abstract

Stoichiometric or catalytic quantities of simple 2° amines greatly increase the rate of H–Zn exchange between ZnPh2 and a range of relatively non-acidic substrates, allowing for the convenient and direct preparation of α-functionalized organozincs.

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