Targeting of mixed sequence double-stranded DNA using pyrene-functionalized 2′-amino-α-l-LNA

Literature Information

Publication Date 2005-07-21
DOI 10.1039/B506986F
Impact Factor 6.222
Authors

Patrick J. Hrdlicka, T. Santhosh Kumar, Jesper Wengel


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Abstract

Incorporation of a single pyrene-functionalized 2′-amino-α-L-LNA monomer X into short DNA strands induces extraordinarily high binding affinity towards complementary DNA (up to 16 °C increase per modification), whereas labile duplexes, suitable as probes for targeting of double stranded DNA, are formed upon positioning of two monomers X in an interstrand +1 zipper motif.

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