Towards the combinatorial synthesis of spongistatin fragment libraries by using asymmetric aldol reactions on solid support

Literature Information

Publication Date 2005-06-15
DOI 10.1039/B505746A
Impact Factor 6.222
Authors

Ian Paterson, Dirk Gottschling, Dirk Menche


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Abstract

By relying on asymmetric boron-mediated aldol reactions, solid phase methodology for the stereoselective synthesis of highly substituted spiroacetals was developed and applied to the preparation of a complex AB-spiroacetal subunit of the antimitotic agent spongistatin 1 (altohyrtin A).

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