Synthesis and cellular uptake of cell delivering PNA–peptide conjugates

Literature Information

Publication Date 2005-06-01
DOI 10.1039/B503777H
Impact Factor 6.222
Authors

Juan J. Díaz-Mochón, Laurent Bialy, Jon Watson, Rosario M. Sánchez-Martín, Mark Bradley


View Original

Abstract

The synthesis and cellular uptake of fluorescently labelled PNA–peptide conjugates is described; Dde/Mmt protected PNA monomers, fully orthogonal to Fmoc chemistry, were used to develop a flexible strategy to give Peptide Nucleic Acids conjugated to tri- and hepta-arginine and the short basic Tat48–57 peptide as examples of cellular penetrating peptides, thereby allowing efficient cellular delivery of PNA into cells.

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