Enhanced relaxation of nanoparticle-bound supercoiled DNA in X-ray radiation

Literature Information

Publication Date 2005-05-24
DOI 10.1039/B503425F
Impact Factor 6.222
Authors

Erika A. Foley, Joshua D. Carter, Fang Shan, Ting Guo


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Abstract

A therapeutic methodology was developed based on the large X-ray absorption cross-section of gold nanoparticles at high photon energies (>81 keV). Experimental results showed that the amounts of the relaxed circular supercoiled DNA (scDNA) for gold nanoparticle-bound scDNA were more than doubled compared to that for free scDNA under otherwise identical radiation conditions.

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