Room temperature palladium catalysed coupling of acyl chlorides with terminal alkynes

Literature Information

Publication Date 2005-01-10
DOI 10.1039/B414826F
Impact Factor 6.222
Authors

Russell J. Cox, Dougal J. Ritson, Thomas A. Dane, John Berge, Jonathan P. H. Charmant, Anob Kantacha


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Abstract

Conditions are reported for the facile, high-yielding coupling of acyl chlorides with terminal alkynes in a reaction involving palladium and copper iodide; the reaction is tolerant of a wide variety of acyl chlorides and terminal alkynes and provides a convenient one-pot route to acetylenic ketones.

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