A method for rapid reaction optimisation in continuous-flow microfluidic reactors using online Raman spectroscopic detection

Literature Information

Publication Date 2004-11-22
DOI 10.1039/B412069H
Impact Factor 4.616
Authors

Shee-Ann Leung, Richard F. Winkle, Robert C. R. Wootton, Andrew J. deMello


View Original

Abstract

An extremely rapid tool for continuous flow synthetic process optimisation is described. A microfluidic reaction system operating in continuous flow is used in conjunction with confocal Raman microscopy to afford rapid molecule synthesis and product quantitation. Accordingly, the approach allows for rapid reaction optimisation within a continuous flow system. Specifically, the catalytic oxidation of isopropyl alcohol (IPA) to acetone using tetra-N-propylammonium perruthanate (TPAP)/N-methylmorpholine N-oxide (NMO) in a radial interdigitated micromixer is studied as a model reaction system. The composition of the reaction effluent can be determined with great facility and information relating to catalyst/co-oxidant ratios, catalyst turnovers and reaction endpoints extracted. Specifically, variation of catalyst and co-oxidant volumetric flow rates between 0 and 50 µL min−1 is used to vary reactant concentrations, define reaction residence times and control product conversions between 0 and 100%. The rapid nature of the system allows chemical information to be gathered and utilised on a sub-minute timescale.

Related Literature

Front cover

Cover

DOI: 10.1039/C1CP90096J

The valence electronic structure and conformational flexibility of epichlorohydrin

M. Alagia, D. Toffoli, M. Speranza, D. Catone, S. Turchini, T. Prosperi, N. Zema, G. Contini, Y. Keheyan

2011-06-10 Paper

DOI: 10.1039/C0CP02730H

An infrared study of solid glycine in environments of astrophysical relevance

Belén Maté, Yamilet Rodriguez-Lazcano, Óscar Gálvez, Isabel Tanarro, Rafael Escribano

2011-06-01 Paper

DOI: 10.1039/C1CP20899C

Complementary and partially complementary DNA duplexes tethered to a functionalized substrate: a molecular dynamics approach to biosensing

Susanna Monti, Ivo Cacelli, Alessandro Ferretti, Giacomo Prampolini, Vincenzo Barone

2011-06-09 Paper

DOI: 10.1039/C1CP21115C

Recent advances and perspectives in four-component Dirac–Kohn–Sham calculations

Leonardo Belpassi, Loriano Storchi, Harry M. Quiney, Francesco Tarantelli

2011-06-13 Perspective

DOI: 10.1039/C1CP20569B

Locking of Turing patterns in the chlorine dioxide–iodine–malonic acid reaction with one-dimensional spatial periodic forcing

Milos Dolnik, Tamás Bánsági, Jr., Sama Ansari, Irving R. Epstein

2011-06-13 Paper

DOI: 10.1039/C1CP20949C

In situ infrared monitoring of the solid/liquid catalyst interface during the three-phase hydrogenation of nitrobenzene over nanosized Au on TiO2

Gilles Richner, Yorck-Michael Neuhold, Martin Makosch, Konrad Hungerbühler

2011-06-09 Paper

DOI: 10.1039/C1CP20238C

Hybrid density functional theory/molecular mechanics calculations of two-photon absorption of dimethylamino nitro stilbene in solution

N. Arul Murugan, Jacob Kongsted, Zilvinas Rinkevicius, Keęstutis Aidas, Kurt V. Mikkelsen, Hans Ågren

2011-06-09 Paper

DOI: 10.1039/C1CP20611G

You might also like

Compound Q&A

What are the main uses of 1H-Indazole-6-carbonitrile (CAS: 141290-59-7)?

1H-Indazole-6-carbonitrile finds applications in pharmaceuticals, where it serve...

141290-59-71H-Indazole-6-carbon...
Compound Q&A

How should waste containing Dioctyl (2E)-2-butenedioate (CAS: 2997-85-5) be handled?

Waste containing Dioctyl (2E)-2-butenedioate (CAS: 2997-85-5) should be collecte...

2997-85-5Dioctyl (2E)-2-buten...
Compound Q&A

What industries use Sodium [(1,2-benzoxazol-3-ylmethyl)sulfonyl]azanide (CAS: 68291-98-5)?

Sodium [(1,2-benzoxazol-3-ylmethyl)sulfonyl]azanide is primarily used in pharmac...

68291-98-5Sodium [(1,2-benzoxa...
Compound Q&A

Are there alternatives to Dimethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,6-pyridinedicarboxylate (CAS: 741709-66-0) in synthesis?

Dimethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,6-pyridinedicarboxyla...

741709-66-0Dimethyl 4-(4,4,5,5-...
Compound Q&A

How should waste containing 2-Fluoro-6-hydrazinopyridine (CAS: 80714-39-2) be handled?

Waste containing 2-Fluoro-6-hydrazinopyridine (CAS: 80714-39-2) should be manage...

80714-39-22-Fluoro-6-hydrazino...
Compound Q&A

What is 6-Formyl-2-pyridinecarboxylic acid (CAS: 499214-11-8)?

6-Formyl-2-pyridinecarboxylic acid is an organic compound with the molecular for...

499214-11-86-Formyl-2-pyridinec...
900874-91-13-(3,4-dimethoxyphen...
Compound Q&A

How is 9H-Tribenzo[b,d,f]azepine (CAS: 29875-73-8) typically synthesized?

9H-Tribenzo[b,d,f]azepine is typically synthesized via a multi-step process invo...

29875-73-89H-Tribenzo[b,d,f]az...
Compound Q&A

How is 1-Cyclopropyl-7-ethoxy-6-fluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid (CAS: 1797982-51-4) typically synthesized?

1-Cyclopropyl-7-ethoxy-6-fluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinolinecarboxyli...

1797982-51-41-Cyclopropyl-7-etho...
Compound Q&A

How should waste containing Methyl 3-oxo-1,2,3,4-tetrahydro-6-quinoxalinecarboxylate (CAS: 671820-52-3) be handled?

Waste containing Methyl 3-oxo-1,2,3,4-tetrahydro-6-quinoxalinecarboxylate (CAS: ...

671820-52-3Methyl 3-oxo-1,2,3,4...

Source Journal

Analyst

Analyst
CiteScore: 7.8
Self-citation Rate: 5.6%
Articles per Year: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Recommended Compounds

Recommended Suppliers

Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.