On-line atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry
Literature Information
Publication Date
2004-06-07
DOI
10.1039/B404178J
Impact Factor
4.616
Authors
Jürg M. Daniel, Sille Ehala, Sebastian D. Friess, Renato Zenobi
View Original
Abstract
A new technique is presented for the coupling of atmospheric pressure matrix-assisted laser desorption/ionization (AP-MALDI) mass spectrometry with liquid delivery systems. Mass measurements of polymers and peptides are demonstrated using a co-dissolved matrix, e.g. α-cyano-4-hydroxycinnamic acid (HCCA). Improvements in terms of sensitivity are achieved by optimizing the shape und control of the exit capillary and by using a laser (355 nm) at a 1 kHz repetition rate. Two calibration experiments promise a good applicability of the presented coupling method for quantitative measurements. The limit of detection achieved so far is 500 nM for peptides in methanol solution containing 25 mM HCCA.
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Source Journal
Analyst
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7.8
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5.6%
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Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
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