Absolute asymmetric synthesis by nucleophilic carbonyl addition using chiral crystals of achiral amides

Literature Information

Publication Date 2004-03-19
DOI 10.1039/B315729F
Impact Factor 6.222
Authors

Masami Sakamoto, Shuichiro Kobaru, Takashi Mino, Tsutomu Fujita


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Abstract

Reaction of the chiral crystals of the achiral amides with n-butyllithium in toluene at −80 °C gave optically active alcohols in 17–84% ee.

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