Simultaneous analysis of hepatotoxic pyrrolizidine alkaloids and N-oxides in comfrey root by LC-ion trap mass spectrometry
Literature Information
Publication Date
2004-01-08
DOI
10.1039/B311030C
Impact Factor
4.616
Authors
Jorgelina C. A. Wuilloud, Samuel R. Gratz, Bryan M. Gamble, Karen A. Wolnik
View Original
Abstract
The purpose of the current study was to develop a LC-MSn method for the analysis of pyrrolizidine alkaloids (PAs) in comfrey. Published data presents an extensive list of PAs and their N-oxides present in comfrey. However, standards are not commercially available for any of the PAs typically present in comfrey. Those PAs that are not stereoisomers were readily resolved on a C18 column using a water–acetonitrile gradient as the mobile phase. The use of a selective technique, LC-MS/MS, allowed us to identify groups of PAs and their N-oxides, as well as identify the number of PAs present in each group, including those that were not completely resolved chromatographically.
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Analyst
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Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
Recommended Compounds
![[3-Chloro-5-(diethylcarbamoyl)phenyl]boronic acid structure](https://static.chemtradehub.com/structs/957/957120-59-1-febc.webp "[3-Chloro-5-(diethylcarbamoyl)phenyl]boronic acid structure")
[3-Chloro-5-(diethylcarbamoyl)phenyl]boronic acid
CAS Number:
957120-59-1
Molecular Formula:
C11H15BClNO3
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