A novel four-component reaction for the synthesis of functionalised dihydropyrimidines
Literature Information
Danielle J. Vugts, Helen Jansen, Rob F. Schmitz, Frans J. J. de Kanter, Romano V. A. Orru
In a multi-component reaction (MCR) of a phosphonate, nitriles, aldehydes and isocyanates, N3-functionalised dihydropyrimidines can be synthesised efficiently via a Horner–Emmons/aza Diels–Alder pathway.
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