A novel four-component reaction for the synthesis of functionalised dihydropyrimidines

Literature Information

Publication Date 2003-09-17
DOI 10.1039/B308243A
Impact Factor 6.222
Authors

Danielle J. Vugts, Helen Jansen, Rob F. Schmitz, Frans J. J. de Kanter, Romano V. A. Orru


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Abstract

In a multi-component reaction (MCR) of a phosphonate, nitriles, aldehydes and isocyanates, N3-functionalised dihydropyrimidines can be synthesised efficiently via a Horner–Emmons/aza Diels–Alder pathway.

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