Drug-induced stabilisation of a mismatched C-T base pair in a DNA hairpin

Literature Information

Publication Date 2003-07-01
DOI 10.1039/B305337G
Impact Factor 6.222
Authors

Cathal T. Gallagher, Mark S. Searle


View Original

Abstract

We have shown that a key feature of drug binding, namely specific G-C base pair recognition at a 5′-TG step, can induce a number of novel structural features when an extrahelical base is inserted in close proximity to the drug binding site; we have clearly demonstrated the formation of a stabilised C-T mismatched base pair at a non-terminal site.

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Inside front cover

Cover

DOI: 10.1039/C7CP90023F

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