An (E)-selective synthesis of trisubstituted (E)-α,β-unsaturated acid derivatives

Literature Information

Publication Date 2003-07-24
DOI 10.1039/B304213H
Impact Factor 6.222
Authors

Fred J. P. Feuillet, Diane E. J. E. Robinson, Steven D. Bull


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Abstract

Potassium alkoxides of N-acyloxazolidin-2-one derived syn-aldolates undergo a novel tandem intramolecular cyclisation elimination reaction to afford trisubstituted (E)-α,β-unsaturated amides in high d.e., which may be converted into their corresponding acids or oxazolines in good yield.

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Contents list

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