Highly enantioselective hydrolysis of alicyclic meso-epoxides with a bacterial epoxide hydrolase from Sphingomonas sp. HXN-200: simple syntheses of alicyclic vicinal trans-diols

Literature Information

Publication Date 2003-03-18
DOI 10.1039/B300435J
Impact Factor 6.222
Authors

Dongliang Chang, Zunsheng Wang, Maarten F. Heringa, Renato Wirthner, Bernard Witholt, Zhi Li


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Abstract

Hydrolysis of N-benzyloxycarbonyl-3,4-epoxy-pyrrolidine and cyclohexene oxide with the epoxide hydrolase of Sphingomonas sp. HXN-200, respectively, gave the corresponding vicinal trans-diols in high ee and yield, representing the first example of enantioselective hydrolysis of a meso-epoxide with a bacterial epoxide hydrolase.

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