Aziridines as a structural motif to conformational restriction of azasugars
Literature Information
José G. Fernández-Bolaños, Vinni H. Lillelund, Mikael Bols
In order to investigate the hypothesis that the glycosidase inhibitor isofagomine was bound to α-or β-glucosidase in a 1,4B conformation, a number of bicyclic aziridines that adopt the 1,4B or B1,4 conformations were synthesised and investigated. (1R)-2-endo,3-exo-2,3-Dihydroxy-4-endo-4-hydroxymethyl-6-azabicyclo[3.1.0]hexane (5) and its N-methyl and N-benzyl analogues and (1S)-2-exo-3-endo-2,3-dihydroxy-4-endo-4-hydroxymethyl-6-azabicyclo[3.1.0]hexane (6) were synthesised. The aziridines 5 and 6 were found to be weak or not inhibitors of α-glucosidase, β-glucosidase and α-fucosidase.
Related Literature
Extending the molecular size in accurate quantum-chemical calculations: the equilibrium structure and spectroscopic properties of uracil
Cristina Puzzarini, Vincenzo Barone
DOI: 10.1039/C0CP02636K
Influence of percentage of guanine molecules, OH radicals, UV irradiation and temperature on electrooxidation of short synthetic oligonucleotides
Anna Maria Nowicka, Ewelina Zabost, Edyta Gilant, Zbigniew Stojek
DOI: 10.1039/C0CP02667K
Iron oxyhydroxide colloid formation by gamma-radiolysis
P. A. Yakabuskie, J. M. Joseph, P. Keech, G. A. Botton, D. Guzonas, J. C. Wren
DOI: 10.1039/C1CP20084D
Fuel-specific influences on the composition of reaction intermediates in premixed flames of three C5H10O2 ester isomers
Bin Yang, Charles K. Westbrook, Terrill A. Cool, Nils Hansen, Katharina Kohse-Höinghaus
DOI: 10.1039/C0CP02065F
High-resolution FTIR spectroscopy of the ν8 and Coriolis perturbation allowed ν12 bands of ketenimine‡
Michael K. Bane, Christopher D. Thompson, Evan G. Robertson, Dominique R. T. Appadoo, Don McNaughton
DOI: 10.1039/C0CP01816C
New insights into diffusion in 3D crowded media by Monte Carlo simulations: effect of size, mobility and spatial distribution of obstacles
Eudald Vilaseca, Adriana Isvoran, Sergio Madurga, Isabel Pastor, Josep Lluís Garcés, Francesc Mas
DOI: 10.1039/C0CP01218A
93Nb NMR and DFT investigation of the polymorphs of NaNbO3
Karen E. Johnston, John M. Griffin, Richard I. Walton, Daniel M. Dawson, Philip Lightfoot, Sharon E. Ashbrook
DOI: 10.1039/C1CP20258H
Solvent-assisted conformational isomerization and the conformationally-pure REMPI spectrum of 3-aminophenol
Woon Yong Sohn, Minho Kim, Sang-Su Kim, Young Dong Park, Hyuk Kang
DOI: 10.1039/C0CP02592E
Iodineoxidation by hydrogen peroxide and Bray–Liebhafsky oscillating reaction: effect of the temperature
Guy Schmitz
DOI: 10.1039/C1CP00006C
Evaluation of a quantitative structure–property relationship (QSPR) for predicting mid-visible refractive index of secondary organic aerosol (SOA)
Haley Redmond, Jonathan E. Thompson
DOI: 10.1039/C0CP02270E
You might also like
How should 2-Methylbenzene-1,4-diamine dihydrochloride (CAS: 615-45-2) be stored?
2-Methylbenzene-1,4-diamine dihydrochloride (CAS: 615-45-2) should be stored in ...
Is (1S,4S)-2,5-Diazabicyclo[2.2.1]heptane dihydrobromide (CAS: 132747-20-7) safe?
(1S,4S)-2,5-Diazabicyclo[2.2.1]heptane dihydrobromide is generally considered sa...
What industries use (6-Chloropyridazin-3-YL)methanamine (CAS: 871826-15-2)?
(6-Chloropyridazin-3-YL)methanamine finds applications in the pharmaceutical ind...
What are the main uses of 2-Fluoro-3-methylphenol (CAS: 77772-72-6)?
2-Fluoro-3-methylphenol is primarily used in the synthesis of pharmaceuticals, p...
What precautions should be taken when handling 3-Methoxy-4-nitrobenzonitrile (CAS: 177476-75-4)?
When handling 3-Methoxy-4-nitrobenzonitrile, it is important to wear appropriate...
What precautions should be taken when handling 1,3-Oxazolo[4,5-b]pyridine-2(3H)-thione (CAS: 211949-57-4)?
When handling 1,3-Oxazolo[4,5-b]pyridine-2(3H)-thione (CAS: 211949-57-4), it is ...
What regulatory guidelines apply to 4-Ethynylbenzamide (CAS: 90347-86-7)?
4-Ethynylbenzamide (CAS: 90347-86-7) falls under various regulatory guidelines i...
What are the main uses of 3-(2-Ethylphenyl)-2-thioxo-4-imidazolidinone (CAS: 186822-57-1)?
3-(2-Ethylphenyl)-2-thioxo-4-imidazolidinone is primarily used as an intermediat...
What is (2-Fluoro-6-methoxyphenyl)acetic acid (CAS: 500912-19-6)?
(2-Fluoro-6-methoxyphenyl)acetic acid, also known as 4-fluoro-3-methoxybenzoic a...
What is the market or research trend for 2-[4-(Hydroxymethyl)phenoxy]ethanol (CAS: 102196-18-9)?
Market trends for 2-[4-(Hydroxymethyl)phenoxy]ethanol (CAS: 102196-18-9) indicat...
Source Journal
Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.










![1H-Imidazo[4,5-c]pyridine-7-carboxylic acid structure 1H-Imidazo[4,5-c]pyridine-7-carboxylic acid structure](https://static.chemtradehub.com/structs/123/1234616-39-7-1344.webp)
![(1R,6R)-6-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)-3-cyclohexene-1-carboxylic acid structure (1R,6R)-6-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)-3-cyclohexene-1-carboxylic acid structure](https://static.chemtradehub.com/structs/865/865689-24-3-5fef.webp)


