Application of hitherto unexplored macrocyclization strategies in the epothilone series: novel epothilone analogs by total synthesis
Literature Information
Publication Date
2002-10-30
DOI
10.1039/B209941A
Impact Factor
6.222
Authors
Jon T. Njardarson, Kaustav Biswas
View Original
Abstract
A total synthesis of Epothilone 490 and a synthesis of 11-hydroxy dEpoB utilizing a vinyl-boronate cross-metathesis followed by a Suzuki macrocyclization. A mild route to reach aldehydes from terminal olefins, anticipating Nozaki–Kishi macrocyclization is described.
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Source Journal
Chemical Communications
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4.7%
Articles per Year:
2458
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![trans-2-{[(Tert-butoxy)carbonyl]amino}cyclobutane-1-carboxylic acid structure](https://static.chemtradehub.com/structs/951/951173-25-4-27cd.webp "trans-2-{[(Tert-butoxy)carbonyl]amino}cyclobutane-1-carboxylic acid structure")
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CAS Number:
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Molecular Formula:
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