Compound Q&A
How is (2E)-3-(3-Chlorophenyl)-N-{2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl}acrylamide (CAS: 2505001-54-5) typically synthesized?
Answer
![(2E)-3-(3-Chlorophenyl)-N-{2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl}acrylamide](https://static.chemtradehub.com/structs/250/2505001-54-5-c1e9.webp "(2E)-3-(3-Chlorophenyl)-N-{2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl}acrylamide")
(2E)-3-(3-Chlorophenyl)-N-{2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl}acrylamide can be synthesized through a multi-step synthetic route involving the condensation of 3-chloroacryloyl chloride with a 1-piperazine derivative carrying a methylsulfonyl group. The reaction is typically performed in the presence of an appropriate base like triethylamine and a suitable solvent like dichloromethane. The overall process requires careful control of pH and temperature to achieve high yield and selectivity.
About
CAS No
2505001-54-5
English Name
(2E)-3-(3-Chlorophenyl)-N-{2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl}acrylamide
Molecular Formula
C16H20ClN3O4S
Molecular Weight
385.87300000000005 g/mol
SMILES
CS(=O)(=O)N1CCN(CC1)C(=O)CNC(=O)/C=C/C1C=C(Cl)C=CC=1
InChIKey
DURMLOBZTVQDGQ-AATRIKPKSA-N
Last Updated: 2026-03-28 19:11
![查看MedChemExpress LLC的(2E)-3-(3-Chlorophenyl)-N-{2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl}acrylamide](https://static.chemtradehub.com/suppliers/67ced0fb2b2de6e8e95a67fd/67ced0fb2b2de6e8e95a67fd-logo.webp){kind=logo}
![查看Shanghai Yuyeh Biotechnology Co., Ltd.的(2E)-3-(3-Chlorophenyl)-N-{2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl}acrylamide](https://static.chemtradehub.com/suppliers/67ce9f132b2de6e8e95a48fe/67ce9f132b2de6e8e95a48fe-logo.webp){kind=logo}