Compound Q&A

How is N-{3-[(2-Cyanoethyl)(ethyl)amino]-4-methoxyphenyl}acetamide (CAS: 19433-94-4) typically synthesized?

Answer

N-{3-[(2-Cyanoethyl)(ethyl)amino]-4-methoxyphenyl}acetamide
N-{3-[(2-Cyanoethyl)(ethyl)amino]-4-methoxyphenyl}acetamide is typically synthesized via a multi-step process involving the reaction of 4-methoxyaniline with 2-(ethoxycarbonylamino)ethyl cyanide followed by acetylation. The synthesis begins with the formation of an intermediate amide, which is then acetylated using acetic anhydride or acetyl chloride. The yield is generally around 70-80%, and the reaction is catalyzed by a suitable base such as triethylamine.

About

CAS No 19433-94-4
English Name N-{3-[(2-Cyanoethyl)(ethyl)amino]-4-methoxyphenyl}acetamide
Molecular Formula C14H19N3O2
Molecular Weight 261.32 g/mol
SMILES CCN(CCC#N)C1=C(C=CC(=C1)NC(=O)C)OC
InChIKey GMJYHCWSTTTWRT-UHFFFAOYSA-N
Last Updated: 2026-03-26 08:46

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