Compound Q&A
How is 1-(Trifluoromethoxy)-4-(trifluoromethyl)benzene (CAS: 80258-33-9) typically synthesized?
Answer
1-(Trifluoromethoxy)-4-(trifluoromethyl)benzene is synthesized through a series of reactions involving the bromination of benzene followed by nucleophilic substitution with trifluoromethyl triflate. The reaction is typically performed in a solvent such as dichloromethane, and the yield is usually around 70-80%. A transition metal catalyst like iron or copper may be used to improve selectivity.
About
CAS No
80258-33-9
English Name
1-(Trifluoromethoxy)-4-(trifluoromethyl)benzene
Molecular Formula
C8H4F6O
Molecular Weight
230.1069999999999 g/mol
SMILES
C1=CC(=CC=C1C(F)(F)F)OC(F)(F)F
InChIKey
PNJSCLOFYSBUMK-UHFFFAOYSA-N
Last Updated: 2026-03-23 00:14
