How is 1-(3-Azetidinyl)-4-piperidinol dihydrochloride (CAS: 810680-60-5) typically synthesized?

1-(3-Azetidinyl)-4-piperidinol dihydrochloride is typically synthesized by reacting 3-azetidinone with piperidine followed by the addition of hydrochloric acid. The reaction involves the formation of a new ring through condensation and subsequent protonation to form the dihydrochloride salt. The yield is generally around 75-85%, and the reaction is carried out under mild conditions to ensure high selectivity.