Compound Q&A
How is Ethyl 1-benzyl-5,5-difluoro-4-hydroxy-3-piperidinecarboxylate (CAS: 1356339-08-6) typically synthesized?
Answer
Ethyl 1-benzyl-5,5-difluoro-4-hydroxy-3-piperidinecarboxylate is typically synthesized via a condensation reaction between 1-benzyl-5,5-difluoro-4-hydroxypiperidine and acetic anhydride. The reaction is catalyzed by a Lewis acid such as aluminum chloride. The process yields up to 85% of the desired product, with good selectivity towards the target compound.
About
CAS No
1356339-08-6
English Name
Ethyl 1-benzyl-5,5-difluoro-4-hydroxy-3-piperidinecarboxylate
Molecular Formula
C15H19F2NO3
Molecular Weight
299.3131 g/mol
SMILES
CCOC(=O)C1CN(CC(C1O)(F)F)Cc1ccccc1
InChIKey
QJGXNZREOAULEI-UHFFFAOYSA-N
Last Updated: 2026-03-22 14:59
