How is (1R,1'S,5R,6'S,8'S)-8'-Chloro-5-hydroxy-2',3',4-trimethoxy-10'-methyl-10'-azaspiro[cyclopentane-1,7'-tricyclo[4.3.3.0~1,6~]dodecane]-2',3-diene-2,4'-dione (CAS: 345641-00-1) typically synthesized?

The compound is typically synthesized via a multi-step organic synthesis route involving alkylation, cyclocondensation, and oxidation reactions. Key steps include the formation of a cyclohexene intermediate, followed by annulation, and finally the introduction of the azaspiro and chloro functionalities. Common catalysts and reagents include sodium hydride, benzoyl peroxide, and dichloromethane, with overall yields ranging from 50-70%.