Compound Q&A

How is 4,5,6,7-Tetrahydro-1H-indazole hydrochloride (CAS: 18161-11-0) typically synthesized?

Answer

4,5,6,7-Tetrahydro-1H-indazole hydrochloride (1:1)
4,5,6,7-Tetrahydro-1H-indazole hydrochloride is typically synthesized from indole or 1H-indazole using electrophilic aromatic substitution followed by N-substitution with a chloride source. The reaction is usually conducted in an inert solvent like dichloromethane or tetrahydrofuran, with a Lewis acid catalyst such as aluminum chloride. Yields are generally high, and the reaction is selective and reproducible.

About

CAS No 18161-11-0
English Name 4,5,6,7-Tetrahydro-1H-indazole hydrochloride (1:1)
Molecular Formula C7H11ClN2
Molecular Weight 158.632 g/mol
SMILES C1CCc2c(C1)[nH]nc2.Cl
InChIKey MRWXPAPXTKTTMR-UHFFFAOYSA-N
Last Updated: 2026-03-11 04:00

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