Compound Q&A

How is 1-(tert-Butyldimethylsilyl)-5-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole (CAS: 1148004-02-7) typically synthesized?

Answer

1-(tert-Butyldimethylsilyl)-5-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole
The compound is typically synthesized using a variety of methods, including boronate ester formation with a fluorous group. Commonly, palladium catalysts are used for cross-coupling reactions. The overall yield is moderate to good, depending on the specific reaction conditions and purity of the starting materials.

About

English Name 1-(tert-Butyldimethylsilyl)-5-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole
Molecular Formula C20H31BFNO2Si
Molecular Weight 375.36900000000014 g/mol
SMILES B1(OC(C(O1)(C)C)(C)C)C2=C(C=CC3=C2C=CN3[Si](C)(C)C(C)(C)C)F
InChIKey OAMAAQPCABOWNH-UHFFFAOYSA-N
Last Updated: 2026-03-08 00:27

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