Compound Q&A
How is 3-Acetyl-4-hydroxyquinolin-2(1H)-one (CAS: 26138-64-7) typically synthesized?
Answer
3-Acetyl-4-hydroxyquinolin-2(1H)-one can be synthesized via a condensation reaction of acetylacetone with 1-hydroxyquinoline in the presence of a suitable base like sodium hydroxide. The reaction is carried out in a solvent such as ethanol, and the yield is typically around 75-80%. Catalytic amounts of Lewis acids like ZnCl2 can enhance the selectivity and yield of the desired product.
About
CAS No
26138-64-7
English Name
3-Acetyl-4-hydroxyquinolin-2(1H)-one
Molecular Formula
C11H9NO3
Molecular Weight
203.197 g/mol
SMILES
CC(=O)C1=C(C2=CC=CC=C2NC1=O)O
InChIKey
UTOJPZBVJLHYGO-UHFFFAOYSA-N
Last Updated: 2026-03-04 21:36
