Compound Q&A
How is 3-Ethyl-5-methyl-1,2-oxazole-4-carboxylic acid (CAS: 17147-85-2) typically synthesized?
Answer
3-Ethyl-5-methyl-1,2-oxazole-4-carboxylic acid is commonly synthesized via the condensation of ethyl isonicotinoyl chloride with methyl ethoxymethylenemalonate. The reaction is typically catalyzed by a Lewis acid like aluminum chloride, with high yields and good selectivity. The process is performed under anhydrous conditions to prevent hydrolysis and deprotonation.
About
CAS No
17147-85-2
English Name
3-Ethyl-5-methyl-1,2-oxazole-4-carboxylic acid
Molecular Formula
C7H9NO3
Molecular Weight
155.153 g/mol
SMILES
CCC1=NOC(=C1C(=O)O)C
InChIKey
RSWFHHWVFZWIMV-UHFFFAOYSA-N
Last Updated: 2026-01-13 15:28
