How is (2E)-N-[2-(2-Methyl-1H-indol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)acrylamide (CAS: 1164462-05-8) typically synthesized?

(2E)-N-[2-(2-Methyl-1H-indol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)acrylamide is usually synthesized via a multi-step process involving the coupling of a substituted indole with an acrylamide derivative. Commonly, Suzuki-Miyaura coupling is employed for this reaction, with Pd(PPh3)4 as a catalyst. The yield is moderate to good, and the product is isolated by column chromatography. The reaction is typically carried out under inert conditions to avoid decomposition.