How is tert-Butyl 4-(prop-2-yn-1-yl)piperazine-1-carboxylate (CAS: 199538-99-3) typically synthesized?

t-Butyl 4-(prop-2-yn-1-yl)piperazine-1-carboxylate is typically synthesized through a multi-step process involving the coupling of tert-butyl 4-(hydroxyimino)-piperazine-1-carboxylate with propargyl bromide. The reaction is catalyzed by a base such as potassium carbonate in an aprotic solvent like N,N-dimethylformamide (DMF). The yield and selectivity can be optimized by adjusting reaction conditions and using phase transfer catalysts.