Compound Q&A
How is 4-(3-Bromophenyl)-1,3-thiazole-2-carboxylic acid (CAS: 808128-00-9) typically synthesized?
Answer
4-(3-Bromophenyl)-1,3-thiazole-2-carboxylic acid is often synthesized via the coupling of 3-bromophenyl isothiocyanate with thiazole-2-carboxylic acid in the presence of a base like triethylamine. The reaction typically occurs at room temperature and yields a product with high selectivity. The reaction is exothermic and should be conducted in an ice bath to control the temperature and ensure a high yield.
About
CAS No
808128-00-9
English Name
4-(3-Bromophenyl)-1,3-thiazole-2-carboxylic acid
Molecular Formula
C10H6BrNO2S
Molecular Weight
284.13399999999996 g/mol
SMILES
C1=CC(=CC(=C1)Br)C2=CSC(=N2)C(=O)O
InChIKey
XNJWWOHVTKHZBG-UHFFFAOYSA-N
Last Updated: 2026-01-01 20:05
