How is Trimetazidine (CAS: 5011-34-7) typically synthesized?

Trimetazidine is typically synthesized through a multistep process involving the condensation of 2,4-dinitroaniline and 2,4-dinitrophenol. The reaction is catalyzed by a Lewis acid and proceeds through a series of intermediates, ultimately yielding Trimetazidine with good yield and selectivity. This method ensures high purity and efficiency in production.