Compound Q&A
How is 4-chloro-N-[5-methyl-2-(7H-pyrrolo[2,3-d]pyrimidine-4-carbonyl)-3-pyridyl]-3-(trifluoromethyl)benzenesulfonamide (CAS: 1100318-47-5) typically synthesized?
Answer
![4-chloro-N-[5-methyl-2-(7H-pyrrolo[2,3-d]pyrimidine-4-carbonyl)-3-pyridyl]-3-(trifluoromethyl)benzenesulfonamide](https://static.chemtradehub.com/structs/110/1100318-47-5-127d.webp "4-chloro-N-[5-methyl-2-(7H-pyrrolo[2,3-d]pyrimidine-4-carbonyl)-3-pyridyl]-3-(trifluoromethyl)benzenesulfonamide")
The compound can be synthesized via a multi-step process involving the coupling of a 7H-pyrrolo[2,3-d]pyrimidine-4-carbonyl moiety with a 5-methyl-2-pyridylamine derivative. A palladium catalyst is often used for the coupling reaction, which achieves a high yield of up to 90%. Further steps include trifluoromethylation and sulfonation reactions.
About
CAS No
1100318-47-5
English Name
4-chloro-N-[5-methyl-2-(7H-pyrrolo[2,3-d]pyrimidine-4-carbonyl)-3-pyridyl]-3-(trifluoromethyl)benzenesulfonamide
Molecular Formula
C20H13ClF3N5O3S
Molecular Weight
495.8700000000001 g/mol
SMILES
Cc1cc(c(nc1)C(=O)c2c3cc[nH]c3ncn2)NS(=O)(=O)c4ccc(c(c4)C(F)(F)F)Cl
InChIKey
LUUMLYXKTPBTQR-UHFFFAOYSA-N
Last Updated: 2025-12-26 02:37
![查看Shanghai Yinxin Laboratory Equipment Co., Ltd.的4-chloro-N-[5-methyl-2-(7H-pyrrolo[2,3-d]pyrimidine-4-carbonyl)-3-pyridyl]-3-(trifluoromethyl)benzenesulfonamide](https://static.chemtradehub.com/suppliers/67cdd97a57537e5c8069adfb/67cdd97a57537e5c8069adfb-logo.webp){kind=logo}
![查看ShangHaiChuangSai Technology Co Ltd的4-chloro-N-[5-methyl-2-(7H-pyrrolo[2,3-d]pyrimidine-4-carbonyl)-3-pyridyl]-3-(trifluoromethyl)benzenesulfonamide](https://static.chemtradehub.com/suppliers/67cecce82b2de6e8e95a5e02/67cecce82b2de6e8e95a5e02-logo.webp){kind=logo}
![查看Shanghai Yuyeh Biotechnology Co., Ltd.的4-chloro-N-[5-methyl-2-(7H-pyrrolo[2,3-d]pyrimidine-4-carbonyl)-3-pyridyl]-3-(trifluoromethyl)benzenesulfonamide](https://static.chemtradehub.com/suppliers/67ce9f132b2de6e8e95a48fe/67ce9f132b2de6e8e95a48fe-logo.webp){kind=logo}