Compound Q&A

How is 5-Bromo-1-phenyl-1H-pyrazole-4-carbonitrile (CAS: 76767-44-7) typically synthesized?

Answer

5-Bromo-1-phenyl-1H-pyrazole-4-carbonitrile
5-Bromo-1-phenyl-1H-pyrazole-4-carbonitrile is synthesized via a multi-step process that includes bromination and subsequent cyclization. Commonly, phenyl azide is brominated using N-bromosuccinimide (NBS) as the brominating agent. The reaction is typically carried out in a chlorinated solvent like dichloromethane under light or heat, followed by cyclization using a suitable base such as potassium carbonate in an aprotic solvent like dimethylformamide (DMF).

About

CAS No 76767-44-7
English Name 5-Bromo-1-phenyl-1H-pyrazole-4-carbonitrile
Molecular Formula C10H6BrN3
Molecular Weight 248.08 g/mol
SMILES C1=CC=C(C=C1)N2C(=C(C=N2)C#N)Br
InChIKey JIMBDAOQQBVANQ-UHFFFAOYSA-N
Last Updated: 2025-12-25 13:43

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