How is 4-amino-2-methylsulfanyl-pyrimidine-5-carbonitrile (CAS: 770-30-9) typically synthesized?

4-Amino-2-methylsulfanyl-pyrimidine-5-carbonitrile (CAS: 770-30-9) can be synthesized through a multi-step process involving the reaction of a substituted pyrimidine with methylsulfanylamine, followed by the introduction of a nitrile group. The synthesis typically involves the use of a Lewis acid as a catalyst to enhance reactivity and improve yield.