How is N-{2-[(5-Chloro-2-{[2-methoxy-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)amino]phenyl}methanesulfonamide (CAS: 1191911-27-9) typically synthesized?

N-{2-[(5-Chloro-2-{[2-methoxy-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)amino]phenyl}methanesulfonamide is synthesized through a multi-step process involving the coupling of 5-chloro-2-aminopyrimidine and 2-methoxy-4-(4-morpholinyl)phenylamine. The reaction is typically carried out in the presence of a suitable catalyst, such as 4-(dimethylamino)pyridine (DMAP), and a base like triethylamine (TEA). The yield is generally high, and the product can be obtained with good purity.