How is 1-{6'-(2-Hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy]-3,3'-bipyridin-6-yl}-3-methylurea (CAS: 1442684-77-6) typically synthesized?

1-{6'-(2-Hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy]-3,3'-bipyridin-6-yl}-3-methylurea is typically synthesized via a multistep reaction involving alkylation of a bipyridine derivative, followed by introduction of the hydroxypropoxy and pyridinyl oxy groups. The synthesis involves the use of mild organic bases and is carried out at room temperature. The overall yield is moderate, around 40-50%, and the method is selective.