Compound Q&A
How is 6-(3-Fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]nicotinamide (CAS: 1033836-12-2) typically synthesized?
Answer
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The compound is typically synthesized via a multi-step process involving protecting group chemistry, amide formation, and ring closure. The key steps include reacting piperidine with 2,2,2-trifluoroethyl chloroformate, followed by reaction with 3-fluorophenyl nicotinamide to form the final product. Catalysts such as HOBt and DMAP are used to improve yield and selectivity.
About
CAS No
1033836-12-2
English Name
6-(3-Fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]nicotinamide
Molecular Formula
C19H19F4N3O
Molecular Weight
381.3730000000001 g/mol
SMILES
c1cc(cc(c1)F)c2ccc(cn2)C(=O)NC3CCN(CC3)CC(F)(F)F
InChIKey
LPUCBGGXXIUBAZ-UHFFFAOYSA-N
Last Updated: 2025-11-01 18:55
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