Compound Q&A

How is 6-Fluoro-1-isoindolinone (CAS: 340702-10-5) typically synthesized?

Answer

6-Fluoro-1-isoindolinone
6-Fluoro-1-isoindolinone can be synthesized by the condensation of 2-fluorophenylacetyl chloride with isoindoline-1,1-dione. The reaction typically involves the use of a base such as pyridine to facilitate the deprotonation and subsequent condensation. The yield is around 70-80%, and the method provides good selectivity for the desired product.

About

English Name 6-Fluoro-1-isoindolinone
Molecular Formula C8H6FNO
Molecular Weight 151.14000000000001 g/mol
SMILES Fc1ccc2CNC(=O)c2c1
InChIKey TWGFYAUQRMVTSI-UHFFFAOYSA-N
Last Updated: 2025-11-01 12:59

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