Compound Q&A
How is (3R)-4-(4-Chlorophenyl)-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)butanoic acid (CAS: 218608-96-9) typically synthesized?
Answer
![(3R)-4-(4-Chlorophenyl)-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)butanoic acid](https://static.chemtradehub.com/structs/218/218608-96-9-f871.webp "(3R)-4-(4-Chlorophenyl)-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)butanoic acid")
This compound is typically synthesized via a multi-step process involving protection of the primary amine, introduction of the chlorine substituent, and subsequent formation of the carbamate group. Commonly used catalysts include HATU and DIPEA, with a yield of around 70-80%. The reaction is carried out in a polar aprotic solvent like DCM or DMF.
About
CAS No
218608-96-9
English Name
(3R)-4-(4-Chlorophenyl)-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)butanoic acid
Molecular Formula
C15H20ClNO4
Molecular Weight
313.78100000000006 g/mol
SMILES
CC(C)(C)OC(=O)NC(CC1=CC=C(C=C1)Cl)CC(=O)O
InChIKey
XHNLLTGZBXJRGH-GFCCVEGCSA-N
Last Updated: 2025-10-29 13:16
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