Compound Q&A
How is 1-Bromo-4-(2,2,2-trifluoroethoxy)benzene (CAS: 106854-77-7) typically synthesized?
Answer
1-Bromo-4-(2,2,2-trifluoroethoxy)benzene can be synthesized via a trifluoroethoxylation reaction of 4-bromoaniline. The reaction typically uses trifluoroethanol and a base like potassium tert-butoxide in an aprotic solvent like dimethyl sulfoxide. The process involves the nucleophilic substitution of the bromine atom by the trifluoroethoxy group, yielding a high yield of the product with good regioselectivity.
About
CAS No
106854-77-7
English Name
1-Bromo-4-(2,2,2-trifluoroethoxy)benzene
Molecular Formula
C8H6BrF3O
Molecular Weight
255.03300000000002 g/mol
SMILES
FC(F)(F)COc1ccc(Br)cc1
InChIKey
SMDIDUHBHCDCRQ-UHFFFAOYSA-N
Last Updated: 2025-10-29 13:16
