How is (E)-N~5~-(Amino{[(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)sulfonyl]amino}methylene)-N~2~-{[(2-methyl-2-propanyl)oxy]carbonyl}-D-ornithine (CAS: 186698-61-3) typically synthesized?

This compound can be synthesized via a multi-step process involving the condensation of D-ornithine with a sulfonyl chloride derivative, followed by amino and methyl ester substitutions. The key steps include protecting group manipulations and selective functional group transformations. The overall yield is moderate, around 50-60%, and the process requires careful control of reaction conditions to achieve high purity.