Compound Q&A
How is 2,2-Difluoro-1,3-benzodioxole-5-carboxylic acid (CAS: 656-46-2) typically synthesized?
Answer
2,2-Difluoro-1,3-benzodioxole-5-carboxylic acid is typically synthesized via the condensation of 2,2-difluoro-1,3-benzodioxole with carboxylic acids using an appropriate coupling agent. Common methods include the use of dicyclohexylcarbodiimide (DCC) or 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) with hydrochloric acid or acetic anhydride as a source of acylating agent. The yield is generally good (70-80%) and the reaction is typically carried out at room temperature.
About
CAS No
656-46-2
English Name
2,2-Difluoro-1,3-benzodioxole-5-carboxylic acid
Molecular Formula
C8H4F2O4
Molecular Weight
202.11199999999997 g/mol
SMILES
C1=CC2=C(C=C1C(=O)O)OC(O2)(F)F
InChIKey
VJLDRFCNFNQTTH-UHFFFAOYSA-N
Last Updated: 2025-10-22 12:37
