How is 5-Bromo-1,2,4-thiadiazole (CAS: 43201-13-4) typically synthesized?

5-Bromo-1,2,4-thiadiazole (CAS: 43201-13-4) is typically synthesized by bromination of 1,2,4-thiadiazole using N-bromosuccinimide (NBS) in an organic solvent like dichloromethane. The reaction is usually carried out at room temperature, and the product can be purified by recrystallization from ethanol. The yield is generally good, and the method is selective for bromination of the thiadiazole ring.