4-BROMO-1H-PYRROLO[2,3-C]PYRIDINE(CAS: 69872-17-9)

4-Bromo-1H-pyrrolo[2,3-c]pyridine is a crystalline solid with a molecular weight of approximately 221.01 g/mol. It has a low solubility in water but is more soluble in organic solvents like DMSO and DMF. This compound is chemically reactive, especially towards nucleophiles, and can undergo substitution reactions. It is also prone to hydrolysis under basic conditions.

4-Bromo-1H-pyrrolo[2,3-c]pyridine can be synthesized through a bromination reaction of 1H-pyrrolo[2,3-c]pyridine using bromine in the presence of a Lewis acid catalyst. The reaction is carried out in a chlorinated solvent, and the yield is typically around 75-80%. The selectivity and purity of the product can be enhanced by using appropriate reaction conditions and purification techniques.

4-Bromo-1H-pyrrolo[2,3-c]pyridine is used in pharmaceuticals for the synthesis of certain drug candidates. It is also utilized in the development of sensors and semiconductors due to its unique electronic and structural properties. Additionally, it has potential applications in polymer synthesis as a building block.

When handling 4-Bromo-1H-pyrrolo[2,3-c]pyridine, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated hood to minimize exposure to bromine vapor. If a spill occurs, it should be carefully cleaned up with appropriate absorbent materials, and the area should be properly decontaminated. Always refer to the safety data sheet (SDS) for detailed handling and emergency procedures.