2-Bromo-1-(4-methylphenyl)-1-propanone(CAS: 1451-82-7)

2-Bromo-1-(4-methylphenyl)-1-propanone is a crystalline solid with a molecular weight of approximately 222.06 g/mol. It is slightly soluble in water but soluble in organic solvents such as ethanol and acetone. It exhibits weak reactivity under normal conditions but can undergo bromine substitution reactions under certain conditions. The compound has a melting point of around 68-69°C and a boiling point of about 220-225°C.

2-Bromo-1-(4-methylphenyl)-1-propanone is typically synthesized by reacting 4-methylphenylacetaldehyde with bromine in the presence of a Lewis acid catalyst such as aluminum bromide. The reaction yields the desired product with good selectivity and moderate to high yield, depending on the reaction conditions and purification methods.

2-Bromo-1-(4-methylphenyl)-1-propanone is used in various industries, including pharmaceuticals, where it serves as a valuable intermediate for drug synthesis. It is also utilized in the production of polymers, sensors, and semiconductors for its unique chemical properties.

When handling 2-Bromo-1-(4-methylphenyl)-1-propanone (CAS: 1451-82-7), appropriate personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. Work should be carried out in a fume hood to minimize exposure to the compound. Spills should be cleaned up with caution, following proper safety protocols. Always consult the Material Safety Data Sheet (MSDS) or Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.